S3E12 | Tirzepatide vs Semaglutide for Obesity — What Did SURMOUNT-5 Teach Us?
Description
Episode Summary
SURMOUNT-5 delivers the first head-to-head comparison of tirzepatide vs semaglutide in adults with obesity but without diabetes.
In this episode, host Dr. Diana Langworthy and expert guest Dr. Kylee Funk (clinical pharmacist in primary care at Mill City Clinic specializing in weight management and diabetes) unpack the trial's design, results, interpretation, safety considerations, and what these findings mean for real-world clinical practice.
Key Takeaways
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Tirzepatide achieved greater weight loss than semaglutide over 72 weeks.
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Both drugs improved cardiometabolic markers with similar safety profiles.
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Open-label design and exclusion criteria affect how broadly results apply.
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Clinical decisions still hinge on access, coverage, tolerability, and goals.
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Featured Study
Aronne LJ, Bade Horn D, le Roux CW, et al. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025;393(1):26-36. doi:10.1056/NEJMoa2416394.
Host
Diana Langworthy, PharmD, BCPS – Associate Professor, University of Minnesota College of Pharmacy
Guest
Kylee Funk, PharmD, BCPS – Clinical Pharmacist in Primary Care, Mill City Clinic (focus: weight management & diabetes)
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